名字：张慧慧

照片：

职称：讲师

专业：病原生物学

电子邮箱：huitomorrow@163.com

通讯地址：至谨楼331

简介：

2015.7-今 吕氏贵宾会0022 讲师

2014.8-2015.6湖南省医学表观基因组学重点实验室 博士后

2009.9-2014.6武汉大学生命科学学院 博士

2005.9-2009.6山东师范大学生命科学学院 学士

主持课题项目：

1.项目负责人：国家自然科学基金面上青年项目（81602450），2017.01-2019.12

4.项目负责人：湖南省自然科学基金青年基金项目（2018JJ3337），2018.01-2020.12

5.项目负责人：湖南省教育厅基金优秀青年项目（16B161），2016.01-2018.12

6.项目负责人：湖南省卫生计生委科研项目C类（C2016045），2016.01-2017.12

代表性学术论文：

1. Zhang, H.H., Li, S.Z., Zhang, Z.Y., Hu, X.M., Hou, P.N., Gao, L., Du, R.L., and Zhang, X.D. (2014). Nemo-like kinase is critical for p53 stabilization and function in response to DNA damage. Cell death and differentiation21, 1656-1663.

2. Zhang, M.H., Zhang, H.H., Du, X.H., Gao, J., Li, C., Shi, H.R., and Li, S.Z. (2019). UCHL3 promotes ovarian cancer progression by stabilizing TRAF2 to activate the NF-kappaB pathway. Oncogene.

3. Li, S.Z., Shu, Q.P., Song, Y., Zhang, H.H., Liu, Y., Jin, B.X., Liuyu, T.Z., Li, C., Huang, X.C., Du, R.L., et al.(2019). Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response. Nature communications10, 3233.

4. Zhao, H., Pan, W.M., Zhang, H.H., Song, Y., Chen, J., Xiang, Y., Gu, B., Li, S.Z., Du, R.L., and Zhang, X.D. (2019). Cancer testis antigen 55 deficiency attenuates colitis-associated colorectal cancer by inhibiting NF-kappaB signaling. Cell death & disease10, 304.

5. Su, T., Zhu, J., Sun, R., Zhang, H., Huang, Q., Zhang, X., Du, R., Qiu, L., and Cao, R. (2019). Design, synthesis and biological evaluation of new quinoline derivatives as potential antitumor agents. European journal of medicinal chemistry178, 154-167.

6. Li, S.Z., Zeng, F., Li, J., Shu, Q.P., Zhang, H.H., Xu, J., Ren, J.W., Zhang, X.D., Song, X.M., and Du, R.L. (2018). Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1. Cancer letters431, 43-53.