姓名:陈适
照片:
![](/__local/5/BF/35/3D2B15D584A7B533E6835018D76_DCE9C8FE_42A7.jpg)
职称:副教授
学位:医学博士
职务:预防医学系主任,预防医学系党支部书记
主要研究方向:职业性肺疾病发病机制
研究生培养:招生方向为劳动卫生与环境卫生学(学硕),公共卫生(专硕),指导的研究生获得国家奖学金,湖南省优秀毕业生等。
电子邮箱:chenshonest@hunnu.edu.cn
个人简介:
陈适,医学博士,副教授,硕士研究生导师。毕业于中国医科大学劳动卫生与环境卫生学专业。现任吕氏贵宾会0022预防医学系主任,支部书记。湖南省青年骨干教师,湖南师范大学“世承人才”计划入选者,湖南师范大学首批“双带头人支部书记工作室”负责人。主要从事职业环境对肺部疾病的机制研究,以及挖掘天然药物产物对职业性肺疾病的治疗。现任湖南省预防医学会毒理学会副主任委员,环境与健康专业委员会副主任委员,劳动卫生专业委员会委员。近5年主持主持国家自然科学基金项目2项,湖南省自然科学基金项目2项,湖南省教育教学改革项目1项。以第一作者或通讯作者发表SCI论文16篇,共发表论文30余篇。担任国家自然科学基金通讯评审专家,Innate Immunity, Journal of Translational Medicine, Laboratory Investigation, Frontiers in Pharmacology等杂志的特邀审稿人。
主持的科研课题:
1.国家自然科学基金面上项目,82173493,TLR4-TRAF6-Beclin1信号轴调控p62介导的肺泡巨噬细胞自噬对矽肺纤维化的作用机制研究,2022/01-2025/12,主持
2.国家自然科学基金青年项目,81703199,p62依赖的选择性自噬对实验性矽肺纤维化的作用及机制研究,2018/01-2020/12,主持
3.湖南省自然科学基金面上项目,2023JJ30423,Galunisertib通过TGF-B信号通路对小鼠矽肺纤维化的作用研究,2023/01-2025/12,主持
4.湖南省自然科学基金青年项目,2019JJ50398,海藻糖通过转录因子EB对小鼠矽肺纤维化的作用研究,2019/01-2021/12,主持
部分代表性论文
1.Shiyi Tan, Shang Yang, Huimin Kang, Ke Zhou, Hanqin Wang, Yujing Zhang,Shi Chen*.Atractylenolide III Ameliorated Autophagy Dysfunction via Epidermal Growth Factor Receptor-Mammalian Target of Rapamycin Signals and Alleviated Silicosis Fibrosis in Mice. Laboratory investigation, 2023;103(2):100024.
2.Rou Li, Huimin Kang,Shi Chen*.From Basic Research to Clinical Practice: Considerations for Treatment Drugs for Silicosis. International Journal of Molecular Sciences, 2023, 24(9):8333.
3.Huimin Kang, Rou Li, Hanqin Wang, Yunfan Zheng,Shi Chen*.Adverse effects of cigarette filter silica on lungs: Comparison with natural crystalline silica particles. Toxicology and Industrial Health,2024, 40(1-2):59-68.
4.Shi Chen;Shiyi Tan; Shang Yang; Gang Chen; Li Zhu; Zhiqian Sun; Haibin Li; Sanqiao Yao*; Nicotine induces apoptosis through exacerbation of blocked alveolar macrophage autophagic degradation in silicosis, Toxicology Letters, 2020, 334: 94-101.
5.Shiyi Tan; Shang Yang; Gang Chen; Li Zhu; Zhiqian Sun;Shi Chen*; Trehalose alleviates apoptosis by protecting the autophagy-lysosomal system in alveolar macrophages during human silicosis, Life Sciences, 2020, 257: 118043.
6.Tan SY, Yang S, Chen MK, Wang YR, Zhu L, Sun ZQ,Shi Chen*;Lipopolysaccharides promote pulmonary fibrosis in silicosis through the aggravation of apoptosis and inflammation in alveolar macrophages. Open Life Sci. 2020; 15: 598-605.
7.Shiyi Tan;Shi Chen *; Macrophage Autophagy and Silicosis: Current Perspective and Latest Insights, International Journal of Molecular Sciences, 2021, 22(1): 453.
8.Chen S, Tang K, Hu P, Tan SY, Yang S, Yang C, Chen G, Luo YX*, Zou H*; Atractylenolide III alleviates the apoptosis through inhibition of autophagy by the mTOR-dependent pathway in alveolar macrophages of human silicosis. Molecular and Cellular Biochemistry. 2021, 476(2): 809-818.
9.Shiyi Tan;Shi Chen *; The Mechanism and Effect of Autophagy, Apoptosis, and Pyroptosis on the Progression of Silicosis. International Journal of Molecular Sciences, 2021, 22(15): 8110.
10.Yujing Zhang; Shuai Huang; Shiyi Tan; Mingke Chen; Shang Yang;Shi Chen*;3-methyadenine inhibits lipopolysaccharides-induced pulmonary inflammation at the early stage of silicosis via blocking NF-κB signaling pathway. Toxicology and Industrial Health, 2021,25: 113-121.