名字:张慧慧
照片:
![](/__local/F/C6/F6/FF54D6EDA28A7D015AD61180D60_5399037D_5D03.jpg)
职称:副教授
研究生招生专业:免疫学,医学技术
电子邮箱:zhanghh87@hunnu.edu.cn
通讯地址:至谨楼331
简介:
张慧慧,副教授,硕士生导师。2009年6月毕业于山东师范大学生命科学学院,获学士学位;2014年6月毕业于武汉大学生命科学学院,获博士学位。目前从事肿瘤发生的分子机制研究。
获得的教学表彰
湖南师范大学第20届青年教师课堂教学竞赛二等奖
主持课题项目:
1.国家自然科学基金青年项目(81602450),2017.01-2019.12
2.湖南省自然科学基金青年基金项目(2018JJ3337),2018.01-2020.12
3.湖南省卫生健康委项目(C2016045),2016.01-2017.12
4.湖南省卫生健康委课题 (202202084830),2022.1-2024.12
社会兼职
湖南省生物化学与分子生物学学会青年委员
代表性学术论文:
1.Huang L, Zhang AQ, Tang CY, Wei JM, Li M, Yuan SS,Zhang HH#, Zhang X#. Identification of potential prognostic markers for lung adenocarcinoma using comprehensive analysis. Mol Med Rep. 2023 Aug;28(2):149. doi: 10.3892/mmr.2023.13036..
2.Zhang HH, Li C, Ren JW, Liu L, Du XH, Gao J, Liu T, Li SZ. OTUB1 facilitates bladder cancer progression by stabilizing ATF6 in response to endoplasmic reticulum stress. Cancer Sci. 2021 Jun;112(6):2199-2209. doi: 10.1111/cas.14876.
3.Zhang HH, Cao RH, Zeng F, Fan W, Guo L, Ma Q, Ke S. Bivalent β-Carbolines Inhibit Colorectal Cancer Growth through Inducing Autophagy. Chem Pharm Bull (Tokyo). 2021;69(11):1104-1109. doi: 10.1248/cpb.c21-00588.
4.Zhang HH, Li YD, Xun Y, Liu H, Wei CX, Wang H, Yang XP, Yuan SS, Liu N, Xiang SL. Polydatin protects neuronal cells from hydrogen peroxide damage by activating CREB/Ngb signaling. Mol Med Rep. 2022 Jan;25(1):9. doi: 10.3892/mmr.2021.12525.
5.Zhang MH,Zhang HH, Du XH, Gao J, Li C, Shi HR, Li SZ. UCHL3 promotes ovarian cancer progression by stabilizing TRAF2 to activate the NF-κB pathway. Oncogene. 2020 Jan;39(2):322-333. doi: 10.1038/s41388-019-0987-z.
6.Zhao H, Pan WM.,Zhang HH, Song, Y, Chen J, Xiang Y, Gu B, Li SZ., Du RL, Zhang XD. (2019). Cancer testis antigen 55 deficiency attenuates colitis-associated colorectal cancer by inhibiting NF-κB signaling. Cell Death Dis. 2019 Apr 3;10(4):304. doi: 10.1038/s41419-019-1537-x.
7.Li, S.Z., Shu, Q.P., Song, Y.,Zhang, H.H., Liu, Y., Jin, B.X., Liuyu, T.Z., Li, C., Huang, X.C., Du, R.L., et al.(2019). Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response. Nature communications10, 3233.
8.Zhao, H., Pan, W.M.,Zhang, H.H., Song, Y., Chen, J., Xiang, Y., Gu, B., Li, S.Z., Du, R.L., and Zhang, X.D. (2019). Cancer testis antigen 55 deficiency attenuates colitis-associated colorectal cancer by inhibiting NF-kappaB signaling. Cell death & disease10, 304.
9.Zhang, H.H., Li, S.Z., Zhang, Z.Y., Hu, X.M., Hou, P.N., Gao, L., Du, R.L., and Zhang, X.D. (2014). Nemo-like kinase is critical for p53 stabilization and function in response to DNA damage. Cell death and differentiation21, 1656-1663.